S-Hexylglutathione
Also known as: Hexyl-GSH, S-n-Hexylglutathione, γ-Glu-Cys(S-hexyl)-Gly
Summary
S-Hexylglutathione is a synthetic glutathione derivative in which the sulfur of glutathione is alkylated with a hexyl chain. It is used primarily as a biochemical tool and affinity ligand for the purification and study of glutathione-binding proteins, particularly glyoxalase I and glutathione S-transferases. It has been investigated for potential antitumor activity given that GLO1 overexpression is associated with multidrug resistance in cancer cells.
Mechanism of Action
Competitive inhibitor of glyoxalase I (GLO1) and glutathione S-transferases (GSTs); binds the active site of these enzymes, blocking detoxification of methylglyoxal and electrophilic substrates. Also inhibits certain multidrug resistance-associated transport proteins.
Routes of Administration
No administration routes recorded yet.
Goals & Uses
- Anticancer research toolOncology / ResearchLow
- Multidrug resistance modulationOncology / ResearchLow
- Glyoxalase I inhibitionEnzyme Inhibition / Biochemical ToolHigh
- Glutathione S-transferase inhibitionEnzyme Inhibition / ResearchHigh
Contraindications
No contraindications recorded yet.
Adverse Effects
No adverse effects recorded yet.
Drug Interactions
No drug interactions recorded yet.
Population Constraints
No population constraints recorded yet.
Regulatory Status
- European UnionUnapprovedNo EMA approval; used solely in laboratory and biochemical research settings.
- United StatesUnapprovedResearch reagent only; not approved or licensed for clinical use by the FDA.
- United KingdomUnapprovedNo MHRA approval; research use only.
No approved clinical use in any jurisdiction. Used exclusively as a research reagent and biochemical tool compound.
Evidence & Sources
No sources recorded yet.