DADLE

Opioid Peptide / Delta Opioid Receptor AgonistRx: ResearchCompound: Research

Also known as: [D-Ala2, D-Leu5]-Enkephalin, 63631-40-3, D-Ala(2)-Leu(5)-Enkephalin, DADLE

Educational Only — Not medical advice. Consult a qualified clinician before using any peptide.

Summary

DADLE ([D-Ala2, D-Leu5]-enkephalin) is a synthetic enkephalin analogue with preferential delta-opioid receptor agonist activity. It has been extensively used in preclinical research to study opioid receptor pharmacology. Notable areas of investigation include neuroprotection, cardioprotection, ischemia/reperfusion injury, and organ preservation. It has also been studied for its ability to induce hibernation-like states in non-hibernating animals.

Mechanism of Action

Selective agonist at delta-opioid receptors (DOR); also has affinity for mu-opioid receptors. Activates Gi/Go proteins, inhibits adenylyl cyclase, modulates ion channels, and reduces neuronal excitability and neurotransmitter release.

Routes of Administration

IntracerebroventricularIntrathecalIntravenousSubcutaneous

Goals & Uses

  • NeuroprotectionNeurologyModerate
  • Cardioprotection / ischemia-reperfusion injuryCardiovascularModerate
  • AntinociceptionResearch / AnalgesiaModerate
  • Organ preservationResearch / TransplantationLow
  • Induction of hibernation-like stateResearch / Suspended AnimationLow
  • Opioid receptor pharmacology toolResearch / Receptor CharacterizationHigh

Contraindications

  • Human therapeutic useRegulatory/safetyHigh
  • Respiratory compromiseClinical (preclinical Extrapolation)High

Adverse Effects

  • Cardiovascular depressionCardiovascularUncommon
  • Respiratory depressionRespiratoryUnknown
  • Sedation / CNS depressionNeurologicalCommon
  • Tolerance and dependencePharmacologicalUnknown

Drug Interactions

  • CNS depressantsHigh
  • Naloxone / NaltrexoneLow

Population Constraints

  • Humans (general)Regulatory / SafetyAbsolute
  • Pregnant animalsReproductiveRelative

Regulatory Status

  • European UnionUnapprovedNo EMA approval; available only as research reagent.
  • United StatesUnapprovedResearch use only; not FDA-approved for any indication. Not scheduled under the Controlled Substances Act but subject to institutional research oversight.
  • United KingdomUnapprovedNo MHRA approval; research use only.

Not approved for human therapeutic use in any jurisdiction. Used exclusively as a research tool compound. Not scheduled as a controlled substance in most jurisdictions, but subject to general research regulations.

Evidence & Sources

No sources recorded yet.

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