Antipain
Also known as: [N-alpha-(N-(N-((S)-1-Carboxy-2-phenylethyl)carbamoyl)-arg-val)]-arginal, Antipain dihydrochloride, Antipain hydrochloride
Summary
Antipain is a natural peptide aldehyde produced by Streptomyces species, used exclusively as a biochemical research tool. It inhibits multiple serine and cysteine proteases and is widely employed in protease inhibitor cocktails for cell lysate preparation and protein purification. It has no approved therapeutic use.
Mechanism of Action
Competitive inhibitor of serine and cysteine proteases, including trypsin, papain, cathepsin B, and plasmin; contains an arginal warhead (aldehyde group) that reversibly forms a covalent hemiacetal with the active site serine or cysteine residue of target proteases
Routes of Administration
No administration routes recorded yet.
Goals & Uses
- Investigation of protease roles in cellular processesResearch/pharmacologyModerate
- Inhibition of cathepsin B activityResearch/biochemistryHigh
- Inhibition of trypsin-like serine proteasesResearch/biochemistryHigh
- Protease inhibition in cell lysatesResearch/biochemistryHigh
Contraindications
No contraindications recorded yet.
Adverse Effects
- Cytotoxicity at high concentrationsIn Vitro ToxicityUncommon
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- Not for human or veterinary therapeutic useGeneralAbsolute
Regulatory Status
- European UnionUnapprovedResearch use only; not EMA approved
- United StatesUnapprovedResearch use only; not FDA approved for any therapeutic indication
- United KingdomUnapprovedResearch use only; not MHRA approved
Not approved for human therapeutic use in any jurisdiction. Sold as a research reagent only. No IND or clinical trial registration documented.
Evidence & Sources
No sources recorded yet.