Acetyl hexapeptide-3

Cosmetic Peptide / Acetylated HexapeptideRx: OtcCompound: Approved

Also known as: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, Acetyl hexapeptide-8, AH3, Argireline

Educational Only — Not medical advice. Consult a qualified clinician before using any peptide.

Summary

Acetyl hexapeptide-3 (Argireline) is a synthetic cosmetic hexapeptide used topically in anti-aging skincare formulations. It is claimed to reduce the depth of facial expression lines by partially inhibiting acetylcholine release at neuromuscular junctions, mimicking a botulinum toxin-like effect in a milder, non-injectable form.

Mechanism of Action

Mimics the N-terminal end of SNAP-25, competitively inhibiting the SNARE complex formation required for vesicle docking and neurotransmitter release, thereby reducing muscle contraction at the neuromuscular junction and attenuating expression wrinkles.

Routes of Administration

Topical

Goals & Uses

  • Skin texture improvementAesthetics / Anti AgingLow
  • Reduction of facial expression wrinklesAesthetics / Anti AgingModerate
  • Non-invasive alternative to botulinum toxinAestheticsLow

Contraindications

  • Application to broken or irritated skinDermatologicalModerate
  • Known hypersensitivity to peptide componentsAllergyHigh

Adverse Effects

  • Contact dermatitisDermatologicalRare
  • Tingling or stinging sensationDermatologicalUncommon
  • Skin irritation / erythemaDermatologicalUncommon

Drug Interactions

  • Botulinum toxin injections (topical co-use)Low

Population Constraints

  • PregnancyReproductive SafetyRelative
  • Infants and young childrenPediatricRelative

Regulatory Status

  • European UnionApprovedApproved: Cosmetic ingredient for topical anti-aging productsListed in EU cosmetic ingredient database; SCCS considers it safe at intended use concentrations.
  • United StatesApprovedApproved: Cosmetic ingredient for topical anti-aging productsRegulated as a cosmetic by the FDA; no drug approval required. Subject to INCI naming conventions.
  • United KingdomApprovedApproved: Cosmetic ingredient for topical anti-aging productsRegulated under UK cosmetics regulation post-Brexit; permitted as cosmetic ingredient.

Regulated as a cosmetic ingredient in the US (FDA), EU (ECHA/SCCS), and UK. Not classified as a drug. No therapeutic claims are permitted. Listed as safe for cosmetic use at concentrations typically up to 10%.

Evidence & Sources

No sources recorded yet.

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